The Single Biggest Genetic Risk Factor that Predisposes You to Cognitive Dysfunction, Alzheimer’s and Cardiovascular Disease 

Your ApoE variant could be responsible for your chronic inflammation and poor cognitive function.

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Our reports are designed for informational purposes only, and not for the treatment or diagnosis of disease. We aim to provide helpful insights and easy to implement lifestyle recommendations to help you achieve your health and wellness goals. You should consult with your doctor before using any recommendations provided in our gene reports, especially if pregnant, nursing, taking medication or have pre-existing medical conditions.

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This DNA Wellness Report is covered by a 30-day Satisfaction Guarantee. If you’re not happy with your purchase, simply contact us at to request a refund.

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What Makes This Report Especially Unique?

Uncover All the Scientific and Biochemical Knowledge to Biohack Your ApoE Genotype

Leave no stone unturned with these features

A comprehensive review of the latest research on the functions and biochemistry of the ApoE gene

A Simple, Step-by-Step Process to Get You Started

Step 1

Once you’ve purchased your DNA Wellness Report, you will receive an email to activate your SelfDecode account. Click on the link and you will be prompted to enter your name and upload your SNP file to your SelfDecode dashboard.

Step 2

Once your SNP file has been uploaded, visit to generate your report.

Download your report to read, learn, take advantage of the personalized recommendations to improve your mood, and share with your healthcare providers.

Step 3

Your ApoE DNA Wellness Report is unique and personalized specifically for you and your health improvement journey.

SelfDecode’s Personalized DNA Wellness Report is more affordable than genetic consults in a medical setting.

Average cost of a 15-minute visit with a genetic counselor:
$150 - $3000

Average cost of a consultation with a health coach:

Average cost of testing for disease genes:

The Team of Experts Behind the ApoE DNA Wellness Report

Nattha Wannissorn
Molecular Genetics

Ana Aleksic
MSc (Pharm)
Clinical Neuroscience 

Frequently Asked Questions

How much do DNA Wellness Reports cost?

SelfDecode paid subscribers receive their Introductory and two premium reports as part of their membership! Upon renewals each year, they will receive two additional DNA Wellness Reports. They can also order more specialized Gene Reports at any time for just $29 each or purchase a 3-report bundle pack for $75 here.

A full individual membership to SelfDecode is available for just $59 per year. We also offer a special discounted family plan that lets you upload gene files for up to three individual members for just $118 per year. The family plan comes with three introductory and six premium reports that can be used by any member on the account.

SelfDecode Professional Plan members have access to all DNA Wellness reports for an unlimited number of  patient files. 

Can I order DNA Wellness Reports even if I am not a SelfDecode member?

Yes! We offer a special membership to SelfDecode that includes access to our Gene Reports without any of the other features included in a full membership. Under this plan, you can order an Introductory Gene Report for $49, as well as our more specialized Gene Reports for $59 each.

What happens after I order my Wellness Report?

After you purchase your DNA Wellness Report, you will be redirected to a page where you can upload your genetic data. You’ll then be able to download your report under the Wellness Reports tab.

Can I see a sample of what is included in a DNA Wellness Report?

Yes! You can look at a sample report using Joe Cohen’s DNA data here.

Where should I get my genes tested?

We recommend 23andme, as our gene reports include the SNPs that are on the latest version of the 23andme chip.
However, you can still use data from other genetic testing services, such as Ancestry and FamilyTreeDNA, if you prefer -- just be aware that not every testing company will include each and every SNP that we analyze in our DNA Wellness Reports.
Please note that we are not a subsidiary or partner of these companies.

What if the most important SNPs are not included in my genome file?

We have specifically designed our DNA Wellness Reports to analyze the SNPs that can give you the most reliable and actionable information about your health. Although individual SNPs are only a small part of your overall genetic profile, we can still make the best out of whatever genetic information you have -- even if it is not totally complete!  Therefore, the interpretation of your SNPs and health advice derived from them should be taken into account in the context of your symptoms, health status, and lifestyle. Even if your genome file is missing certain SNPs, our software will take into account all available data to generate your DNA Wellness Report and to make appropriate lifestyle recommendations. 

How do I know my data is secure?

We take your privacy and data security very seriously. This is why we employ multiple layers of data protection, including:

Secured data encryption.

Restricting employee access to personally identifiable information.

Only collecting the minimum information necessary to provide you with your requested services.

We do not and will not sell or make available any of your data to third-party companies.

Your payment is processed by secured and reputable companies such as PayPal and Stripe.

You can read our privacy policy here.

The ApoE gene is the most significant known cause of Alzheimer’s disease and mild cognitive impairment.

It both increases the overall risk and reduces the age of onset.

Poor ApoE function can lead to mild cognitive impairment, Alzheimer’s, and cardiovascular disease.

Up to 60% of Alzheimer’s patients are ApoE-ε4 carriers. Among the carriers, post-menopausal women are at the highest risk of developing Alzheimer’s disease.

Fortunately, these ApoE variants are two of the most studied human genetic variants that existed, and there are many practical steps you take to improve your odds, once you’re aware of your genotype.

ApoE is responsible for:

Protecting neurons and the brain

Reducing oxidative stress

Protecting against infections

Controlling the immune response and inflammation

The transport and metabolism of fats and cholesterol

PPAR-γ function and the ApoE gene

Reduced ApoE function can raise your cholesterol and make your brain more susceptible to damage. The ApoE-ε4 genotype results in significantly lower function and levels of the ApoE protein.


The PPAR-γ protein is responsible for controlling the production of the ApoE proteins and several activators of PPAR-γ have been proposed as preventive or treatment drugs for Alzheimer’s.

SelfDecode’s ApoE DNA Wellness Report includes ways to assess your PPAR-γ function and naturally ensure that your PPAR-γ gene works optimally.

Health Risks Associated with the ApoE-ε2 Allele

Contrary to popular belief, the ApoE-ε2 allele actually decreases the function of ApoE. Although this variant of ApoE-ε2 is neuroprotective, it does confer its own health risks.

For this genotype, it becomes even more important to regularly monitor blood work and live a lifestyle that is compatible with your ApoE-ε2 variant.


Reduce triglycerides

Reduce risks of Type-III hyperlipoproteinemia

Manage blood sugar

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Covers All Research Published to Date About the ApoE Gene and Your Variants
This is the first report that covers all published information about the ApoE gene and your variants. This report has 154 scientific references written by our molecular geneticist and neuroscientist.

An interpretation of your ApoE genotype

Health risks and benefits of your ApoE genotype

Detailed diet, lifestyle, and supplement recommendations based on SelfHacked’s Proprietary Biochemical Analysis and clinical experience optimizing cognitive function for over 1,000 clients

A Modified Mediterranean Diet Guide to Reduce Your Risks of Alzheimer’s

Jonathan Ritter
PhD (Pharmacology)

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