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Optimize Your Health With a Genetic Methylation Test
Discover how genes like MTHFR affect your detox, energy, and wellness, and receive personalized recommendations to optimize your health.
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Understand Your Methylation Genes for Optimal Health
The Methylation Pathway Report breaks down your genetic blueprint, focusing on critical genes that affect detoxification, energy, and overall wellness. With clear, actionable insights, this report empowers you to take the steps that truly work for your body.
- Easy at-home genetic methylation test for insights into MTHFR variants and more
- Clear and actionable report tailored to your genetics
- Personalized recommendations to optimize your health based on your DNA
Why Get a Genetic Methylation Test
Learn how your methylation genes may contribute to issues like fatigue, poor detoxification, or immune imbalances.
Identify genetic weaknesses and get targeted recommendations to address them effectively.
Understand how your unique genetic blueprint shapes your health and unlock strategies to support optimal performance.
See how key genes influence methylation.
The Methylation Pathway Report analyzes 30 SNPs (Genetic Variants) across 20+ key genes involved in this process, such as MTHFR, COMT, and PEMT, to reveal how your genetics influence detox, energy, and more.
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Methylation Report
- Methylation Report
- 30 SNPs across 20+ key methylation genes
- SelfDecode DNA Kit
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- Includes Methylation Report & Full Health Analysis!
- SelfDecode DNA Kit
- 1250+ DNA Health Reports with Personalized Recommendations
- Lifestyle & Longevity Risk Assessments
- 24/7 AI Health Coach & Unlimited Labs Analyzer Access
- +130 Medical Reports & Medication Check (PGx Testing)
- Family Planning (Carrier Status) & Ancestry Reports
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More Than a Genetic Methylation Test
Personalized Recommendations
Get tailored diet, supplement, and lifestyle suggestions based on your health risks and goals.
1250+ DNA Health Reports
Explore personalized insights into 1250+ health topics using advanced polygenic risk scores.
Lab Tracking
Optimize 4,000+ lab markers with personalized guidance.
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Receive custom meal plans, recipes, and shopping lists tailored to your body.
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Get a personalized list of suggested lab tests based on your DNA & health goals.
SNP & Gene Search Tool
Discover your genotype for any SNP in our database of 200M+ genetic variants.
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Unlock Your Methylation and 1250+ Other DNA Health Reports
Go beyond with a genetic methylation test that provides a comprehensive look into 30 SNPs across 20+ key methylation genes. Gain actionable insights to optimize detoxification, energy levels, and hormone balance while understanding how your genes impact your overall health.
FAQs
What is methylation?
A methylation test analyzes specific patterns of methylation in your genome. Methylation is a process that can affect gene expression and is influenced by factors such as diet, lifestyle, environment, and age.
Our report focuses on reactions known as one-carbon metabolism, which help remove homocysteine with the help of nutrients like folate, vitamin B12, choline, and more. It can provide valuable insights into your genetic health and help decode how your genes influence detox, brain health, heart health, energy production, and inflammation. Understanding your genetic predispositions helps you make targeted lifestyle and dietary adjustments to support your health.
What’s the Importance of Healthy Methylation?
Healthy methylation is essential for regulating gene expression, DNA repair, detoxification, and maintaining cellular function. Disruptions in methylation can lead to health problems, including an increased risk of chronic diseases like cancer, cardiovascular issues, cognitive decline, fertility problems, and more.
Who would benefit most from this Genetic Methylation Test?
Anyone interested in learning more about their genetic health could benefit from a methylation test. It is especially useful for people who are looking to optimize their health, reduce disease risks, or understand genetic factors related to: Detoxification, Hormone control, Neurotransmitters, Energy production, Inflammation, Homocysteine metabolism, Liver detoxification, Immune system support, DNA repair.
Since this complex process occurs in every cell, as well as in brain fluids and the liver, it impacts many vital bodily functions.
How does your genetic Methylation Test differ from other at home tests?
Our methylation test is backed by scientific research and uses the latest technology to provide highly accurate, comprehensive results. We analyze 24 genes, including MTHFR, COMT, MTRR, CBS, PEMT, and more.
With this report, you’ll gain personalized insights into how your genes impact methylation and receive clear, actionable recommendations on:
Dietary strategies: Optimize your intake of methylation-supporting nutrients like folate, vitamin B6, and B12.
Supplement recommendations: Understand which vitamins, minerals, and cofactors may help improve your methylation function.
Lifestyle adjustments: Learn how environmental factors, stress, and toxins influence your genetic pathways and how to mitigate risks.
What are the key methylation cycles you analyse?
The report covers three key cycles: folate cycle, methionine cycle, and transsulfuration. They interact with each other to control methylation, folate metabolism, vitamin B12 utilization, homocysteine clearance, detoxification, and more.
Age range a genetic methylation test is suitable for?
A genetic methylation test is suitable for individuals aged 18 and older. It can be useful across a wide age range, as methylation patterns can provide insights into aging, disease risk, and overall health, making it relevant for both younger and older adults seeking to understand their genetic health.
How long will it take to get my genetic methylation test results?
Typically, you can expect to receive your results within 2-4 weeks after your sample has been received at our lab. We provide detailed, easy-to-understand reports that break down your methylation markers and health insights.
What are symptoms of poor methylation?
Symptoms of poor methylation can include fatigue, mood disorders (like anxiety or depression), difficulty concentrating (brain fog), and frequent infections. It may also lead to an increased risk of chronic conditions such as cardiovascular disease, hormonal imbalances, and neurological disorders.
Does insurance cover this test?
Currently, most insurance plans do not cover the cost of methylation testing. But you can use your FSA/HSA card to pay for this test
How do I interpret my methylation test results?
Once you receive your results, you’ll get an easy-to-understand report with actionable insights and health recommendations.
Will this test show how well my body processes nutrients?
Yes, the methylation report includes insights into how well your body metabolizes key nutrients such as folate, B12, and choline, which are critical for effective methylation. Genetic variants related to these nutrients are assessed to provide personalized guidance on supplementation or dietary adjustments.
Can I change my methylation profile through lifestyle changes?
Yes, lifestyle choices such as diet, exercise, and stress management can influence your methylation pathways. By understanding which areas of your methylation cycle may be compromised, you can make informed decisions about food choices, supplements, and other interventions that could support your health.
What genes are covered in the Folate Cycle?
CUBN, DHFR, FOLH1, FUT2, MTHFD1, MTHFD1L, MTHFR, MTHFS, MTR, MTRR, SHMT1, TCN2, TYMS
What genes are covered in the Methionine Cycle?
AHCY, BHMT, CHDH, COMT, DNMT3B, GNMT, MAT1A, PEMT
What genes are covered in Transsulfuration?
CBS, PDXK
What is the MTHFR gene, and how does it affect my methylation?
The MTHFR gene produces an enzyme that helps convert folate into its active form, methylfolate, which is crucial for the methylation process. Variants in this gene, such as MTHFR C677T, can reduce the enzyme’s effectiveness, potentially leading to higher homocysteine levels, which are linked to increased risks of heart disease, stroke, and pregnancy complications.
What does the MTHFR C677T variant mean for my health?
The MTHFR C677T variant can significantly reduce the activity of the MTHFR enzyme, leading to difficulties in processing folate and elevated homocysteine levels. Individuals with this variant may be at higher risk for cognitive issues, heart disease, mental health disorders, and birth defects, making it important to monitor and manage folate intake.
What is the role of the COMT gene in methylation?
The COMT gene encodes an enzyme involved in the breakdown of neurotransmitters through methylation. COMT plays a key role in regulating stress responses and cognitive function through methylation. Variants like the COMT Val158Met can affect stress tolerance, mood, and cognitive performance, with individuals carrying two copies of the “A” allele being more sensitive to stress.
Shipping Worldwide
HSA/FSA Eligible
Methylation Report
- Methylation Report
- 30 SNPs across 20+ key methylation genes
- SelfDecode DNA Kit
DNA DAY 45% OFF SALE
Ultimate Bundle
- Includes Methylation Report & Full Health Analysis!
- SelfDecode DNA Kit
- 1250+ DNA Health Reports with Personalized Recommendations
- Lifestyle & Longevity Risk Assessments
- 24/7 AI Health Coach & Unlimited Labs Analyzer Access
- +130 Medical Reports & Medication Check (PGx Testing)
- Family Planning (Carrier Status) & Ancestry Reports
We will never share your data
We follow HIPAA and GDPR policies
We have World-Class Encryption & Security
Rated 4.7/5 from 750+ reviews
200,000+ users, 2,000+ doctors & 80+ businesses
SelfDecode is a personalized health report service, which enables users to obtain detailed information and reports based on their genome. SelfDecode strongly encourages those who use our service to consult and work with an experienced healthcare provider as our services are not to replace the relationship with a licensed doctor or regular medical screenings.