The Single Biggest Genetic Risk Factor that Predisposes You to Cognitive Dysfunction, Alzheimer’s and Cardiovascular Issues 

Your ApoE variant could be responsible for your chronic inflammation and poor cognitive function.

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Our reports are designed for informational purposes only, and not for the treatment or diagnosis of disease. We aim to provide helpful insights and easy to implement lifestyle recommendations to help you achieve your health and wellness goals. You should consult with your doctor before using any recommendations provided in our gene reports, especially if pregnant, nursing, taking medication or have pre-existing medical conditions.

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Unlock the ApoE DNA Wellness Report Now

What Makes This Report Unique?

It Uncovers All the Scientific and Biochemical Knowledge Needed to Biohack Your ApoE Genotype

Leave no stone unturned with these features

Comprehensive review of the latest research on the functions and biochemistry of the ApoE gene

A Simple, Step-by-Step Process to Get You Started

Step 1

Once you’ve purchased your DNA Wellness Report, visit your SelfDecode Dashboard to upload or select the DNA file for which you want to generate your report.

Step 2

Once your SNP file has been uploaded, visit the Wellness Reports page to generate your report.

Download or print your report to see the personalized recommendations and share with your healthcare providers. 

Step 3

Your ApoE DNA Wellness Report is unique and personalized specifically for you and your health improvement journey.

SelfDecode's Personalized ApoE Wellness Report

$4000   $1000   $200

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Unlock the ApoE DNA Wellness Report Now

SelfDecode’s Personalized DNA Wellness Report is more affordable than genetic consults in a medical setting.

Average cost of a 15-minute visit with a genetic counselor:
$150 - $3000

Average cost of a consultation with a health coach:

Average cost of testing for disease genes:

The Team of Experts Behind the ApoE DNA Wellness Report

Nattha Wannissorn
Molecular Genetics

Ana Aleksic
MSc (Pharm)
Clinical Neuroscience 

Frequently Asked Questions

How much do DNA Wellness Reports cost?

SelfDecode members receive the Introductory DNA Wellness Report and five specialized reports of their choice with their subscription. Members also receive five additional DNA Wellness Reports for free each time they renew their annual subscription, which allows them to easily keep up with the new reports we release! 

Members can also order additional specialized DNA Wellness Reports at any time for just $29 each, or purchase a 3-report bundle pack for $65. 

A full individual membership to SelfDecode is available for $97 per year. We also offer a lifetime access package that includes all current and future reports, as well as exclusive access to our personalized SelfDecode blog. 

Additionally, we offer a SelfDecode Professional Plan to help medical practitioners bring the advantages of genetic analysis into their own practice. This plan grants full access to all of our DNA Wellness Reports, as well as an unlimited number of gene file uploads to help you service all of your patients.

Can I order DNA Wellness Reports even if I am not a SelfDecode member?

Yes! We offer a special membership to SelfDecode that includes access to our DNA Wellness Reports without the other features included in a full membership. Under this plan, you can purchase an Introductory DNA Wellness Report for $49, or order one of our specialized DNA Wellness Reports for $59 each.

What happens after I order my DNA Wellness Report?

After you purchase your DNA Wellness Report, you will be redirected to a page where you can upload your genetic data. You’ll then be able to download your report under the “Wellness Reports” tab.

Can I see a sample of what is included in a DNA Wellness Report?

Yes! You can look at a sample report using Joe Cohen’s DNA data here.

Where should I get my genes tested?

If you're getting your genes tested for the first time, we recommend ordering one of our specially-designed SelfDecode testing kits here. We have specially curated the SNPs tested by our chip to ensure that you get the most value out of SelfDecode and our DNA Wellness Reports

However, you can also use data from other companies! To ensure that everyone can benefit from our DNA Wellness Reports, we always make sure to include plenty of SNPs that are also available on chips from other companies (such as 23andMe, and FamilyTreeDNA). So if you’ve already gotten your genes sequenced by another service, don’t worry: you will still have enough SNP coverage to get plenty of value out of your DNA Wellness Reports!

What if the most important SNPs are not included in my genome file?

We have specifically selected the SNPs and genes featured in our reports to be compatible with all of the most popular genotyping chips. 

In addition, our proprietary SelfDecode polygenic risk score algorithm enables us to make the best out of whatever genetic information you have on file -- even if it’s missing some SNPs! 

Therefore, no matter where you got your genome sequenced, SelfDecode’s DNA Wellness Reports will be able to help identify your unique genetic strengths and weaknesses, as well as give you personalized recommendations to fix or improve them even further.

How do I know my data is secure?

We take your privacy and data security very seriously. This is why we employ multiple layers of data protection, including: 

  • Secured data encryption 
  • Restricting internal access to any personally-identifying information 
  • Only collecting the minimum information necessary to provide you with the requested services 
  • Payment processing by secure and reputable companies, such as PayPal and Stripe 

We also do not (and will never) give away or sell any of your data to third-party companies. 

You can read our full privacy policy here.

The ApoE gene is the most significant known cause of Alzheimer’s disease and mild cognitive impairment.

It both increases the overall risk and reduces the age of onset.

Poor ApoE function can lead to mild cognitive impairment, Alzheimer’s, and cardiovascular disease.

Up to 60% of Alzheimer’s patients are ApoE-ε4 carriers. Among the carriers, post-menopausal women are at the highest risk of developing Alzheimer’s disease.

Fortunately, these ApoE variants are two of the most studied human genetic variants that exist, and there are many practical steps you take to improve your odds once you’re aware of your genotype.

ApoE is responsible for:

Protecting neurons and the brain

Reducing oxidative stress

Protecting against infections

Controlling the immune response and inflammation

The transport and metabolism of fats and cholesterol

PPAR-γ function and the ApoE gene

Reduced ApoE function can raise your cholesterol and make your brain more susceptible to damage. The ApoE-ε4 genotype results in significantly lower function and levels of the ApoE protein.


The PPAR-γ protein is responsible for controlling the production of the ApoE proteins and several activators of PPAR-γ have been proposed as preventive or treatment drugs for Alzheimer’s.

SelfDecode’s ApoE DNA Wellness Report tells you how to assess your PPAR-γ function and ensure that your PPAR-γ gene works optimally.

Health Risks Associated with the ApoE-ε2 Allele

Contrary to popular belief, the ApoE-ε2 allele actually decreases the function of ApoE. Although this variant of ApoE-ε2 is neuroprotective, it does confer its own health risks.

For this genotype, it becomes even more important to regularly monitor blood work and live a lifestyle that is compatible with your ApoE-ε2 variant.


Reduce triglycerides

Reduce risks of Type-III hyperlipoproteinemia

Manage blood sugar

Unlock the ApoE DNA Wellness Report Now

This is the first report that covers all published information about the ApoE gene and your variants. It was written by SelfDecode's team of molecular genetics and neuroscience experts, with 154 citations to the latest scientific studies.

Thorough interpretation of your ApoE genotype

Health risks and benefits of your ApoE genotype

Detailed diet, lifestyle, and supplement recommendations based on SelfHacked’s Proprietary Biochemical Analysis and clinical experience optimizing cognitive function for over 1,000 clients

Modified Mediterranean Diet guide to reduce your risks of Alzheimer’s

Jonathan Ritter
PhD (Pharmacology)

Unlock the ApoE DNA Wellness Report Now

How do I know this DNA Wellness Report is for me?

If you've been struggling with chronic inflammation or poor cognitive function, then this report could have the answers you've been looking for. Additionally, this report is particularly useful for people looking for more information about their risk factors for Cognitive Dysfunction, Alzheimer's and Cardiovascular Disease. 

This report doesn't merely contain generic recommendations about the ApoE gene. It provides targeted recommendations and information about health risks based on your personal DNA.